新しい肺血管抵抗モデル開発のための基礎検討

DOI

書誌事項

タイトル別名
  • Preliminary study for the development of a sophisticated pulmonary vascular resistance model

抄録

The authors have been developing a pulmonary mechanical simulator in order to establish a design parameters of a novel artificial cardiovascular devices. In pulmonary circulation, interactive pressure-flow changes are regulated by pulmonary impedance characteristics. We focused on the native impedance characteristics variation in the pulmonary circulation. To examine the effect of respiratory control on pulmonary resistance, we measured pulmonary arterial pressure and flow in adult goat under the different respiratory settings with open/closed-chest condition. Pulmonary input impedance in two respiratory conditions under the anesthetized open-chest positive pressure ventilation (PPV) and the awake spontaneous respiration (SR) were calculated. Longitudinal impedance at 0 Hz in SR showed lower than in PPV, and at high harmonic area in SR was bigger than in PPV. In order to examine the hemodynamic response for newly designed artificial internal organs, pulmonary impedance variation caused by respiratory control should be considered. For sophisticated pulmonary resistance model, reproducing the negative pressure condition in the thoracic cavity, and pulmonic vascular resistance regulation might be required.

収録刊行物

  • 生体医工学

    生体医工学 53 (Supplement), S200_01-S200_01, 2015

    公益社団法人 日本生体医工学会

詳細情報 詳細情報について

  • CRID
    1390001205266238720
  • NII論文ID
    130005163639
  • DOI
    10.11239/jsmbe.53.s200_01
  • ISSN
    18814379
    1347443X
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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