心虚血・再灌流研究におけるマイクロダイアリシス法の有用性

DOI
  • 秋山 剛
    国立循環器病研究センター　心臓生理機能部

書誌事項

タイトル別名
  • Microdialysis technique during myocardial ischemia-reperfusion

説明

<p>Microdialysis technique has been first developed for monitoring neurotransmitter release in the brain. We have applied this technique to the heart and monitored myocardial interstitial levels of endogenous substances including norepinephrine, serotonin, and their metabolites during myocardial ischemia-reperfusion. Cardiac microdialysis technique is a powerful tool for investigating the pathological changes within the ischemic region during myocardial ischemia-reperfusion. Advantages of using microdialysis technique during myocardial ischemia-reperfusion are following: 1) simultaneous monitoring myocardial interstitial levels of endogenous substances in both ischemic and non-ischemic regions of the heart; 2) continuous monitoring in the ischemic region during ischemia as well as after reperfusion; 3) local administration of pharmacological agents into the ischemic region without systemic effects. Although microdialysis technique has several disadvantages, cardiac microdialysis technique has been widely used at present. In this session, we would like to explore advantages of using microdialysis technique during myocardial ischemia-reperfusion by showing practical data.</p>

収録刊行物

  • 生体医工学

    生体医工学 54Annual (26AM-Abstract), S24-S24, 2016

    公益社団法人 日本生体医工学会

詳細情報 詳細情報について

  • CRID
    1390001205267298048
  • NII論文ID
    130005285131
  • DOI
    10.11239/jsmbe.54annual.s24
  • ISSN
    18814379
    1347443X
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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