書誌事項
- タイトル別名
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- Dependence of Diffusion Weighted MR Signal Intensities on Imaging Parameters and Restricted Size
- カクサン キョウチョウ MR シンゴウ キョウド ノ サツゾウ パラメータ ナラビニ セイゲン サイズ イソンセイ ニ カンスル ケントウ
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抄録
Neuronal cells in the human brain has minute and intricate structures in which a lot of water molecules diffuse restrictedly. In recent years, DWI has been focusd on as a method which can detect restricted diffusion of water molecules and visualize the structures containing water molecules. This approach is mainly used for diagnosis of pathology such as acute stroke. In addition, lately it has been suggested that this approach can be applied to fMRI with the fact that neuronal cells in the brain change their volumes during their activation. In the present study, with the Monte-Calro method we simulated the motions of water molecules in the restricted structures whose sizes were similar to those of neurons to find appropriate imaging parametrs for DW-fMRI. Simulation results demonstrated that imaging parameters and the size of restricted areas may change signal intensities. Furthermore, it was found that the difference of signal intensities due to the change in the size of restricted areas largely depends on the q-value which is one of imaging parameters. These results indicate that the present simulation can estimate the imaging parameters which emphasize the difference of signal intensities in DWI between before and after the sizes of cells change. In addition, we should choose appropriate q-value more carefully than b-value for the measurements of brain activations with DWI.
収録刊行物
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- 生体医工学
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生体医工学 48 (3), 281-290, 2010
公益社団法人 日本生体医工学会
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詳細情報 詳細情報について
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- CRID
- 1390001205268002304
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- NII論文ID
- 10031199771
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- NII書誌ID
- AA11633569
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- ISSN
- 18814379
- 1347443X
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- NDL書誌ID
- 10777304
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可