Artificial Organ Made in vivo —Valve Leaflet of the Jellyfish Valve—
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- KISHI Ayumi
- Graduate School of Medical Science, Kitasato University
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- ISOYAMA Takashi
- Department of Biomedical Engineering, University of Tokyo
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- SAITO Itsuro
- Research Center for Advanced Science and Technology, University of Tokyo
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- KOUNO Akimasa
- Department of Biomedical Engineering, University of Tokyo
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- ONO Toshiya
- Department of Biomedical Engineering, University of Tokyo
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- SUGINO Ayaka
- Department of Biomedical Engineering, University of Tokyo
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- MITSUMUNE Norihiko
- Research Center for Advanced Science and Technology, University of Tokyo
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- YAMAGUCHI Sachiko
- Department of Biomedical Engineering, University of Tokyo
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- SHI Wei
- Department of Biomedical Engineering, University of Tokyo
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- INOUE Yusuke
- Department of Biomedical Engineering, University of Tokyo
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- NAKAGAWA Hidemoto
- Research Center for Advanced Science and Technology, University of Tokyo
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- ABE Yusuke
- Department of Biomedical Engineering, University of Tokyo
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- IMACHI Kou
- TUBERO, Tohoku University
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- NOSHIRO Makoto
- Graduate School of Medical Science, Kitasato University
Bibliographic Information
- Other Title
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- 生体内で作る人工臓器ジェリーフィッシュ弁・弁葉
- 生体内で作る人工臟器ジェリーフィッシュ弁・弁葉
- セイタイナイ デ ツクル ジンコウ ゾウキ ジェリーフィッシュベン ベンヨウ
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Abstract
Artificial materials used for artificial organs have sufficient strength and durability. However, their biocompatibility has not been improved yet to the level of tissue-derived biomaterials. On the other hand, there were some problems in artificial organs made of tissue-derived biomaterials; difficulty of forming the desired shapes, insufficiency of strength and durability, and infection control. It is necessary to build arbitrarily-shaped artificial organs that have sufficient strength and durability with tissue-derived biomaterials. In this study, we developed an in-vivo method to make a circle valve leaflet of a jellyfish valve using an insert molding technique. The jellyfish valve is an artificial valve developed at the University of Tokyo, and consists of the valve leaflet and a valve seat. The three types of molds for valve leaflets with different thickness (0.5 mm, 1.0 mm, and 1.2 mm) were made with an acrylic resin. A velour cloth was put inside each mold to ensure strength and durability. Two sets of molds were built; one with only suspended cell and another with both suspended cell and tissue fragments. Three types of molds were implanted under the skin of a goat. The performance and durability of jellyfish valves with tissue-engineered valve leaflets were assessed using a mock circulation circuit after the molds were extracted from the goats and the valve leaflets were fixed with formalin. Moreover, hematoxylin-and-eosin stained sections were observed. The results demonstrated that the valve leaflets covered with connective tissues have sufficient performance and durability of more than one month. In conclusion, we made a tissue-engineered circle valve leaflet with enough strength and durability to be used as heart valves in vivo using the insert molding technique.
Journal
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- Transactions of Japanese Society for Medical and Biological Engineering
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Transactions of Japanese Society for Medical and Biological Engineering 45 (4), 267-273, 2007
Japanese Society for Medical and Biological Engineering
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Details 詳細情報について
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- CRID
- 1390001205268414080
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- NII Article ID
- 110006614029
- 130004494014
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- NII Book ID
- AA11633569
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- ISSN
- 18814379
- 1347443X
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- NDL BIB ID
- 9389178
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed