Fatty liver with ultrasonographic bright pancreas may have higher affinity for metabolic syndrome

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  • KOMIYAMA Yasuhiro
    Department of Clinical Laboratory, Osaka Railway Hospital Department of Medical Nutrition, Graduate School of Life Science, Osaka City University
  • MOMOKI Chika
    Department of Medical Nutrition, Graduate School of Life Science, Osaka City University
  • HABU Daiki
    Department of Medical Nutrition, Graduate School of Life Science, Osaka City University
  • MORI Takahiro
    Department of Gastroenterology, Osaka Railway Hospital
  • ITO Tadashi
    Department of Gastroenterology, Osaka Railway Hospital
  • SHIMIZU Seiji
    Department of Gastroenterology, Osaka Railway Hospital
  • MIZUNO Shigeto
    Department of Medical Pharmaceutics, Kobe Pharmaceutical University

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Other Title
  • 腹部エコー上の高輝度膵を有する脂肪肝は, メタボリック症候群を高頻度に併存する
  • フクブ エコー ジョウ ノ コウキドスイ オ ユウスル シボウ カン ワ,メタボリック ショウコウグン オ コウヒンド ニ ヘイソン スル

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Abstract

(Objective) The most frequently observed abnormality in abdominal ultrasonography is fatty liver. However, it is difficult to conduct thorough examination in all patients with fatty liver. In recent years, fat accumulation in the pancreas has attracted attention as a risk factor of arteriosclerotic disease. In this study, we focused on the degree of fat accumulation in the pancreas for the purpose of extracting fatty livers with a greater risk of arteriosclerosis. <BR>(Subjective and Methods) One hundred and twenty one patients with fatty liver were investigated. As an index to show the degree of fat accumulation in the pancreas, brightness was evaluated by histogram values and the difference in brightness between the pancreas and spleen was indicated as the “pancreas-spleen difference.” <BR>(Results) In patients with fatty liver, receiver operating characteristic analysis (ROC) was performed for the pancreas-spleen difference with the presence or absence of concurrent metabolic syndrome as the outcome, and the pancreas-spleen difference cutoff value was set at 45. It resulted in moderate accuracy with sensitivity of 0.652, specificity of 0.702, and area under the curve (AUC) of 0.705. The patients in the group with a high pancreas-spleen difference had concurrent metabolic syndrome at a higher frequency and had higher values of visceral fat area, higher body weight, higher BMI and higher abdominal circumference, suggesting that it is a group of patients with fatty liver with a greater risk of arteriosclerosis. <BR>(Conclusion) It was indicated that adding the pancreas-spleen difference to the ultrasonic screening test could extract types of fatty livers that have high affinity for metabolic syndrome.

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