Is Lubiprostone + Sodium Diatrizoate Effective in Bowel Preparation for Computed Tomographic colonography? —A Novel Regimen without Lavage Solution—

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  • 大腸CT検査の前処置にルビプロストン＋水溶性造影剤は有用か？─腸管洗浄剤を使用しない新たな前処置法の試み─
  • 大腸CT検査の前処置にルビプロストン+水溶性造影剤は有用か? : 腸管洗浄剤を使用しない新たな前処置法の試み
  • ダイチョウ CT ケンサ ノ マエショチ ニ ルビプロストン+スイヨウセイゾウエイザイ ワ ユウヨウ カ? : チョウカン センジョウザイ オ シヨウ シナイ アラタ ナ マエショチホウ ノ ココロミ

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Abstract

Aim: To evaluate the efficacy of lubiprostone in computed tomographic (CT) colonography regimen.<BR>Methods: We evaluated 204 patients who underwent CT colonography in one institution from January 2015. Lubiprostone 24μg + iodinated contrast medium 50 ml was administered twice (once on the night before, and once on the morning of the day of the procedure). Sixteen patients had severe dehydration due to diarrhea. Hence, the patients received only half of the lubiprostone dose. A reader graded residual fluid (0: none to 3: >50% circumference), residual stool (0: none to 3: >10 mm), and fecal tagging quality (0: heterogeneous to 4: homogeneous) at six segments of the large intestine. The mean values of all factors were calculated in each segment. In addition, patient acceptability was evaluated.<BR>Result: The median score (interquartile range) was 1.67 (1.17-2.17) for residual fluid, 0 (0-0.33) for residual stool, and 4 (3.83-4) for tagging homogeneity. Of the patients, 71% reported that preparation was easy.<BR>Conclusion: Lubiprostone + sodium diatrizoate was effective in bowel preparation for CT colonography and could be used as the standard regimen in the future.

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