Effect of albumin animal species on photosensitization reaction progress and protein oxidization

DOI
  • Ogawa Emiyu
    Keio University Graduate School of Science and Technology
  • Arai Tsunenori
    Keio University Graduate School of Science and Technology Keio University, School of Science and Technology, Department of Applied Physics and Physico-Informatics

Bibliographic Information

Other Title
  • 光増感反応におけるアルブミン動物種が反応進行およびタンパク酸化に与える影響

Abstract

<p>We have developed a new catheter ablation methodology for tachyarrhythmia using photosensitization reaction using talaporfin sodium to reduce complications. We intend to use extracellular singlet oxygen production to realize immediate electrical conduction block by laser irradiation just after the photosensitizer administration. It is reported that the albumin structure different along animal species and binding and cell killing are different. We investigated the photosensitization reaction progress by fluorescence measurement around 700 nm and albumin oxidization by ultraviolet region absorbance using human, bovine, and canine albumin. We found that the albumin oxidization behavior using canine albumin was similar to that of human albumin. The bovine albumin was easily oxidized.</p>

Journal

Details 詳細情報について

  • CRID
    1390001205269944448
  • NII Article ID
    130006077076
  • DOI
    10.11239/jsmbe.55annual.385
  • ISSN
    18814379
    1347443X
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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