Estimation of gastric atrophy based on serum pepsinogens measured after eradication of <i>Helicobacter pylori</i>

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  • FURUTA Takahisa
    Center for Clinical Research Hamamatsu University School of Medicine
  • SAHARA Shu
    First Department of Medicine Hamamatsu University School of Medicine
  • ICHIKAWA Hitomi
    First Department of Medicine Hamamatsu University School of Medicine
  • KAGAMI Takuma
    First Department of Medicine Hamamatsu University School of Medicine

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Other Title
  • 除菌後血清ペプシノゲン(PG)値からの除菌前の萎縮性胃炎, PG法の陽性・陰性の推定
  • ジョキン ゴ ケッセイ ペプシノゲン(PG)アタイ カラ ノ ジョキン マエ ノ イシュクセイ イエン,PGホウ ノ ヨウセイ ・ インセイ ノ スイテイ

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Abstract

We assessed whether serum levels of pepsinogen (PG) measured after eradication of H. pylori could be a marker of gastric atrophy before eradication. Serum levels of PG I/II and anti-H. pylori IgG antibody were measured before and after eradication of H. pylori in a total of 193 patients who underwent gastroscopy. Gastric atrophy was evaluated according to the Kimura-Takemoto classification. When subjects were classified by the results of the PG method, PG I and PG I/II ratios after eradication could distinguish the PG method-positives from negatives. When the cut of 36.5 ng/ml was used, the validity for the estimation of positive or negative for PG method was 74.2%. This criterion correlated well with the gastric atrophy based on Kimura-Takemoto classification. Therefore, serum PGs measured after eradication of H. pylori could reflect gastric atrophy before eradication.

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