TOWARDS THE ESTABLISHMENT OF A SAFE CELL-FREE AND CONCENTRATED ASCITES REINFUSION THERAPY

DOI 2 Citations 6 References
  • Okamoto Yoshio
    Department of Transfusion Medicine and Cell Processing, Tokyo Women's Medical University
  • Nakahashi Yoshinobu
    Department of Transfusion Medicine and Cell Processing, Tokyo Women's Medical University
  • Chino Mineko
    Department of Transfusion Medicine and Cell Processing, Tokyo Women's Medical University
  • Matsuda Kazuki
    Department of Transfusion Medicine and Cell Processing, Tokyo Women's Medical University
  • Kubota Tomoaki
    Department of Transfusion Medicine and Cell Processing, Tokyo Women's Medical University
  • Okada Shinichi
    Department of Transfusion Medicine and Cell Processing, Tokyo Women's Medical University
  • Moriya Tomomi
    Department of Transfusion Medicine and Cell Processing, Tokyo Women's Medical University
  • Oikawa Miyuki
    Department of Transfusion Medicine and Cell Processing, Tokyo Women's Medical University
  • Lee Maiko
    Department of Transfusion Medicine and Cell Processing, Tokyo Women's Medical University
  • Kinoshita Akemi
    Department of Transfusion Medicine and Cell Processing, Tokyo Women's Medical University
  • Aoki Masahiro
    Department of Transfusion Medicine and Cell Processing, Tokyo Women's Medical University
  • Kogen Yumi
    Department of Transfusion Medicine and Cell Processing, Tokyo Women's Medical University
  • Nakabayashi Kyoko
    Department of Transfusion Medicine and Cell Processing, Tokyo Women's Medical University
  • Konno Mayumi
    Department of Transfusion Medicine and Cell Processing, Tokyo Women's Medical University
  • Utsugisawa Taiju
    Department of Transfusion Medicine and Cell Processing, Tokyo Women's Medical University
  • Iribe Yuji
    Department of Transfusion Medicine and Cell Processing, Tokyo Women's Medical University
  • Ogura Hiromi
    Department of Transfusion Medicine and Cell Processing, Tokyo Women's Medical University
  • Kanno Hitoshi
    Department of Transfusion Medicine and Cell Processing, Tokyo Women's Medical University
  • Fujii Hisaichi
    Department of Transfusion Medicine and Cell Processing, Tokyo Women's Medical University

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Other Title
  • 腹水濾過濃縮再静注法（CART）の安全性確立に向けて

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Cell-free and concentrated ascites reinfusion therapy (CART) has been applied for over 30 years in the treatment of patients with intractable ascites (or pleural effusion): collected ascites (pleural effusion) is filtered, concentrated, and reinfused intravenously into the patient. Since the purified ascites might be accidentally administered to other patients in large-scale hospitals, we decided to establish a computer-aided system, similar to that used in blood transfusion, to enable safer management by using bar-code labels.<br> We next examined biochemical properties, including total protein and albumin concentration, of ascites before and after filtration/concentration, and found that the mean recovery of albumin was 66.8%, and mean albumin content was 26.5±2.7g after processing.<br> We also introduced a rapid testing system for endotoxin, which enabled us to show that purified ascites does not contain harmful levels of endotoxin (over 0.1EU/ml). Finally, biochemical properties as well as endotoxin concentration were not significantly altered after storage either overnight at 4°C or for 14 days at -30°C, suggesting that it may be possible to perform CART after overnight storage in refrigerators or provide purified ascites after cryopreservation.<br> Since the present guideline suggests that albumin products should be avoided for end-stage patients, CART might be useful in cancer patients with intractable ascites in palliative care units.<br>

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