GRANULOCYTE TRANSFUSION FROM A DONOR WITH Jk<sup>a</sup>-POSITIVE RED CELLS TO A CHILD PATIENT WITH ANTI-Jk<sup>a</sup>

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  • Takano Nozomi
    Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University Hospital
  • Kawabata Kinuyo
    Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University Hospital
  • Yasuda Hiroyasu
    Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University Hospital
  • Ohhara Yoshihiro
    Department of Pediatric Oncology, Fukushima Medical University Hospital
  • Waragai Tomoko
    Department of Pediatric Oncology, Fukushima Medical University Hospital
  • Sano Hideki
    Department of Pediatric Oncology, Fukushima Medical University Hospital
  • Kikuta Atsushi
    Department of Pediatric Oncology, Fukushima Medical University Hospital
  • Ohto Hitoshi
    Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University Hospital

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Other Title
  • 抗Jk<sup>a</sup>を保有する重症感染症患者へのJk<sup>a</sup>不適合赤血球を含有する顆粒球輸血

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Abstract

<p>We report a case of aplastic anemia in a child complicated by severe infection, for which granulocytes with incompatible red cells (total 160 ml) were transfused. A pediatric patient known to have anti-Jka antibodies (titer 1) developed sepsis and multi-organ failure during immunosuppressive therapy. An ABO-compatible related donor was found to be Jk (a+b-). In this instance, no hemolytic transfusion reaction was observed. Among Japanese, only 30% of ABO-compatible donors are Jk (a-). After granulocyte transfusion, the direct antiglobulin test remained negative and anti-Jka titers did not rise. No hemolysis of Jk (a+) red cells was evident from biochemical and serological tests.</p>

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