Synthetic studies on biologically active site components of bacterial endotoxins, lipid As.

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  • 細菌内毒素の活性部位リピドＡ類の合成研究
  • サイキンナイ ドクソ ノ カッセイ ブイ リピド Aルイ ノ ゴウセイ ケンキ

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Abstract

New Methodology for efficient synthesis of biologically active site components of bacterial lipopolysaccharides, lipid A and the related compounds was developed. From novel key intermediates bearing chemically differentiated one amino and four hydroxyl groups or two amino and six hydroxyl groups, lipid X, Y, glucosamine-4-phosphoric acid derivatives and lipid As were synthesized. These chemically synthesized compounds possess interesting biological activities.

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