Synthetic and Medicinal Chemistry of Trifluoromethyl Ketones.

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  • トリフルオロメチルケトン類の新規合成法の開発と創薬
  • トリフルオロメチル ケトンルイ ノ シンキ ゴウセイホウ ノ カイハツ ト ソウヤク

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Abstract

Trifluoromethyl ketones (TFMKs) are of considerable current interest due to their importance as synthetic intermediates and their ability to act as potent enzyme inhibitors. This article briefly reviews recent ten-years progress in the chemistry of TFMKs and describes our studies on the new method for the preparation of TFMKs. Furthermore, screenings of a variety of structurally diverse TFMKs, with the view to identify a lead TFMK with anti-Helicobacter pylori, antimicrobial or apoptosis-inducing and -inhibitory activities are shown. These studies led to the identification of several TFMKs as a lead molecule.

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