Total Synthesis of Biologically Active Compounds Related to Plant Disease and the Physiological Function.

  • Toshima Hiroaki
    Department of Bioresource Science, College of Agriculture, Ibaraki University

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Total synthesis of biologically active compounds related to plant disease and the physiological function has been accomplished. Coronatine, its related compounds, β-resorcylic acid derivatives, decumbic acid, aliphatic δ-lactones, cepaciamides, and piscidic acids, were selected as the synthetic targets. In these syntheses, the chiral pool method and catalytic asymmetric synthesis were also applied to introduce the requisite stereogenic centers. Combination of the two methods made it possible to synthesize a sufficient amount of the required enantiomers and diastereomers for biological studies.

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