Molecular Design of Artificial Saccharide Receptors.

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  • TAKEUCHI Masayuki
    Department of Chemistry & Biochemistry, Graduate School of Engineering, Kyushu University

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  • ボロン酸を用いた人工糖質レセプターの設計と機能
  • ボロンサン オ モチイタ ジンコウ トウシツ レセプター ノ セッケイ ト キ

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Abstract

For the development of new receptor molecules that can precisely recognize sugar molecules, we synthesized a number of diboronic acids. Since one boronic acid can react with two OH groups (one diol group) to form a boronate ester, one diboronic acid can immobilize two diol units to form a sugarcontaining macrocycle. The selectivity can be tuned by the relative spatial position of the two boronic acids and the complexation event can be read out by circular dichroism, UV-Vis, and fluorescence spectroscopy. The nature presents a variety of saccharide structures to us which are already utilized as a “recognition tag” or a “supramolecular building-blocks” in the life processes. If we gain some efficient interfaces to control chemical and physical properties of saccharides, it will become possible to mimic this chemistry in artificial systems. As a research target to challenge this new concept, we can now raise three examples which are currently studied in our laboratory.

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