オリゴ糖鎖ライブラリーの作製

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  • Preparation of Oligosaccharide Units Library.
  • オリゴトウサ ライブラリーノ サクセイ

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Significant attentions have been focused on the application of glycosidase-catalyzed transglycosylation for practical synthesis of oligosaccharides involved in glycoconjugates. The enzymatic synthesis has become more practical by the use of several glycosidases available in sufficient quantity. This review describes convenient syntheses of di and trisaccharide units, which are related to molecular recognition, by employing regioselective transgalactosylation, trans-N-acetylglucosaminidation, transfucosylation and transmannosylation. The regioselectivity could be manipulated to some extent by using following techniques : (1) careful selection of enzymes, (2) organic co-solvent system, (3) inclusion complex of acceptor glycoside with cyclodextrin.

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