Adsorption and Desorption of Insulin on Porous Hydroxyapatite Microspheres
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- SHI Hai-Tao
- West China School of Pharmacy, Sichuan University
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- GONG Tao
- West China School of Pharmacy, Sichuan University
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- LIU Shi-Wei
- West China School of Pharmacy, Sichuan University
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- CHEN Shu
- West China School of Pharmacy, Sichuan University
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- ZHANG Zhi-Rong
- West China School of Pharmacy, Sichuan University
Bibliographic Information
- Other Title
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- 水酸アパタイトミクロスフェア多孔体におけるインシュリンの吸脱着
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Abstract
In this study, porous hydroxyapatite microspheres with the size range 9-80 μm have been prepared by a spray-drying method and the possibility using this kind of microspheres as carrier for peptides has been investigated with insulin being chosen as a model drug. In adsorption experiment, many factors (i.e., incubation temperature, incubation duration, pH and concentration of insulin solution) had influences on insulin adsorption on obtained microspheres. More than 90% insulin in solution could be loaded with optimal combination of these factors and drug loading of more than 3% could be achieved. In desorption experiment, the concentration of dipotassium hydrogen phosphate solution in many effecting factors had greatest influence on insulin release from insulin-adsorbed microspheres. More than 90% loaded-insulin could be released at dipotassium hydrogen phosphate solution at concentration around 10 mM. All these results suggested that there was possibility of fabrication of proteinic drug delivery system with porous hydroxyapatite microspheres.<br>
Journal
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- Journal of the Ceramic Society of Japan
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Journal of the Ceramic Society of Japan 113 (1321), 579-583, 2005
The Ceramic Society of Japan
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Details 詳細情報について
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- CRID
- 1390001205277259904
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- NII Article ID
- 110002292386
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- NII Book ID
- AN10040326
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- ISSN
- 18821022
- 09145400
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- NDL BIB ID
- 7468512
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed