微生物，酵素反応により得た光学活性物質を利用する生理活性物質の新規合成法の開発

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  • New syntheses of physiologically active compounds using the chiral synthons produced by microbial or enzymatic reactions.
  • ビセイブツ コウソハンノウ ニ ヨリ エタ コウガク カッセイ ブッシツ オ

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The combination of microbial or enzymatic reactions and organic syntheses is effective for preparation of various physiologically active compounds. New preparative methods of versatile optically active compounds by microbial oxidation, microbial reduction and enzymatic hydrolysis are described and their utilization on the syntheses of several physiologically active compounds (angiotensin converting enzyme inhibitor, intermediate of β-lactam antibiotic syntheses, β-adrenergic blocking agents etc.) are described.

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