Behavior of β-tricalcium phosphate granules composed of rod-shaped particles in the rat tibia

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  • OKUMURA Teruhito
    Department of Regenerative Oral Surgery, Nagasaki University Graduate School of Biomedical Sciences
  • GONDA Yoshinori
    Department of Oral Pathology and Bone Metabolism, Nagasaki University Graduate School of Biomedical Sciences Department of Orthopedic Surgery, School of Medicine, Juntendo University
  • IOKU Koji
    Graduate School of Environmental Studies, Tohoku University
  • KAMITAKAHARA Masanobu
    Graduate School of Environmental Studies, Tohoku University
  • OKUDA Takatoshi
    Department of Orthopedic Surgery, School of Medicine, Juntendo University
  • YONEZAWA Ikuho
    Department of Orthopedic Surgery, School of Medicine, Juntendo University
  • KUROSAWA Hisashi
    Department of Orthopedic Surgery, School of Medicine, Juntendo University
  • ASAHINA Izumi
    Department of Regenerative Oral Surgery, Nagasaki University Graduate School of Biomedical Sciences
  • IKEDA Tohru
    Department of Oral Pathology and Bone Metabolism, Nagasaki University Graduate School of Biomedical Sciences

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タイトル別名
  • Behavior of .BETA.-tricalcium phosphate granules composed of rod-shaped particles in the rat tibia
  • Behavior of v tricalcium phosphate granules composed of rod shaped particles in the rat tibia

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Porous spherical granules of β-tricalcium phosphate (β-TCP) composed of rod-shaped particles were prepared via a hydrothermal route. The biological significance of implantation of the spherical β-TCP granules for healing of bone defects was analyzed by implantation into 2 mm diameter and 3 mm deep defects created in tibiae of 9-week-old Wistar rats. Implantation of spherical β-TCP contributed to regeneration of bone tissue. At 2 and 4 weeks after implantation, numerous alkaline phosphatase-positive cells appeared around the implant and newly formed bone. At 8 weeks after implantation, residual implants were mostly embedded in bone tissue. Without implantation, bone defects healed with a much lower amount of bone. In addition, bone marrow adipocytes were considerably fewer in tibiae with implants compared to tibiae without implants at 4 and 8 weeks after the operation. These data suggested that implanted β-TCP granules worked as scaffolds to maintain alkaline phosphatase-positive cells and also resulted in less fatty change of bone marrow.

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