卵巣摘出ラットにおける尿中NTXの推移と腰椎の骨密度および組織的変化の関係

DOI
  • 北村 文月
    Department of Fundamental Nursing, Faculty of Nursing
  • 黒川 清
    Department of Anatomy, Faculty of Medicine, Shiga University of Medical Science
  • 今本 喜久子
    Department of Fundamental Nursing, Faculty of Nursing

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タイトル別名
  • Relationships between the Transition of Urinary NTX and Changes of Lumbar BMD and of Cancellous Bony Tissue in Ovariectomized Rats

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説明

Using bilaterally ovariectomized (OVX) rats, we observed relationships between the transition of type I collagen cross-linked N-telopeptide (NTX) in urine and changes of the lumbar bone mineral density (BMD) and of the cancellous bony tissue.<BR>The values of urinary NTX indicated a transient increase, that is, the peak appeared on the second week after OVX in rats ovariectomized at 12 weeks of age, and on the first week after OVX in rat ovariectomized at 19 weeks of age. Sham-operated and intact controls indicated no particular elevation of NTX. Then, the NTX values returned to the control level within 3-5 weeks after OVX. On the other hand, the average of lumbar BMDs measured on the eighth week after OVX showed a slight increase (0.8%) in rats ovariectomized at 12 weeks of age and an obvious decrease (-3.9%) in rats ovariectomized at 19 weeks of age, although those in the controls increased moderately in each group (6.2% and 4.3%, respectively) .<BR>The lumbar vertebral bodies at L2-L5 were sectioned at midsagittal plane and prepared for the tartrate-resistant acid phosphatase (TRAP) reaction, then image-analyzed in 4.25mm2near the epiphyseal plate. On the eighth week after OVX at 12 weeks of age, the number of TRAP positive osteoclasts and the total area of positive cells seemed to increase in the lumbar cancellous bone, suggesting the diminution of trabeculae.

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  • 形態・機能

    形態・機能 5 (2), 89-96, 2007

    コ・メディカル形態機能学会

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