Application of Serum TARC Levels in Clinical Practice for Atopic Dermatitis

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  • アトピー性皮膚炎診療における血清TARC値の活用
  • アトピーセイ ヒフエン シンリョウ ニ オケル ケッセイ TARCチ ノ カツヨウ

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<p>　Peripheral blood eosinophil count, serum levels of LDH, and total IgE have traditionally been employed as biomarkers for disease severity and activity of atopic dermatitis. Chemokine TARC (thymus and activation-regulated chemokine) has been introduced as a new biomarker. TARC plays important roles in the pathogenesis of atopic dermatitis ; and serum TARC levels are much higher in patients with atopic dermatitis than in those with other skin diseases, and vary with disease severity, reflecting disease activity. Moreover, their value changes rapidly and greatly. Therefore, they are more useful than conventional biomarkers, for this type of monitoring. In addition, using serum TARC levels, it is possible to show patients therapeutic outcomes as mathematical values, and thereby enhance motivation for treatment. Monthly measurements of serum TARC are covered by insurance in Japan. A novel measurement method was developed, whose results can be obtained in a very short time, enabling doctors to review them before examining patients.</p>

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