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Moderate Angiotensin I Converting Enzyme (ACE) Inhibitor from the Fruit Body of Sarcodon aspratus
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- KIYOTO Masaaki
- Laboratory of Bioresource Science, Department of Applied and Environmental Chemistry, Kitami Institute of Technology
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- SUZUKI Hiroyuki
- Laboratory of Bioresource Science, Department of Applied and Environmental Chemistry, Kitami Institute of Technology
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- HARA Takaaki
- Hakuju Life Science Co., Ltd.
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- YAGI Yuzo
- Hakuju Life Science Co., Ltd.
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- CHO Nam-Seok
- College of Agriculture, Life & Environmental Science, Chungbuk National University
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- AOYAMA Masakazu
- Laboratory of Bioresource Science, Department of Applied and Environmental Chemistry, Kitami Institute of Technology
Bibliographic Information
- Other Title
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- コウタケ子実体に含まれる温和なACE阻害物質
- Moderate Angiotensin 1 Converting Enzyme (ACE) Inhibitor from the Fruit Body of Sarcodon aspratus
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Description
The acetone extract from the fruit body of Sarcodon aspratus (Berk.) S. Ito showed moderate angiotensin I converting enzyme (ACE) inhibitory activity, dMannitol was isolated from S. aspratus by sequential extraction with w-hexane and acetone followed by purification with activated char powder. Yield of the compound was 0.3% based on dry material. D-Arabitol was also found in the acetone extract. These compounds showed moderate ACE inhibitory activities, and the concentrations required to inhibit 50% of the ACE activity (IC_<50>) were 33.4 and 34.5mg/ml, respectively. The inhibition patterns on ACE of these two polyhydric alcohols and D-sorbitol (IC_<50> value: 31.9mg/ml) were investigated using LineweaverBurk plots. As a result, they acted as competitive inhibitors for ACE, suggesting that they are antagonists against the substrate binding to the active site of ACE. These results also indicated that polyhydric alcohols that consisted of a straight chain with more than five carbon atoms were more potent inhibitors.
Journal
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- Mushroom Science and Biotechnology
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Mushroom Science and Biotechnology 13 (4), 189-194, 2005
Japanese Society of Mushroom Science and Biotechnology
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Details 詳細情報について
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- CRID
- 1390001205287414144
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- NII Article ID
- 110008675273
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- NII Book ID
- AA12415767
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- ISSN
- 24327069
- 13487388
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- NDL BIB ID
- 7844056
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL Search
- CiNii Articles
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- Abstract License Flag
- Disallowed