A Case of Recurrent Pleomorphic Liposarcoma that Exhibited a Remarkable Response to Hyperthermoradiotherapy

DOI Web Site 11 References
  • ABE TAKANORI
    Department of Radiation Oncology, International Medical Center, Saitama Medical University Department of Radiation Oncology, Gunma University Graduate School of Medicine
  • EBARA TAKESHI
    Department of Radiation Oncology, International Medical Center, Saitama Medical University
  • HARADA KOSAKU
    Department of Radiation Oncology, Isesaki Municipal Hospital
  • SHIRAI KATSUYUKI
    Department of Radiation Oncology, Gunma University Graduate School of Medicine
  • SHIOYA MARIKO
    Department of Radiation Oncology, Fujioka General Hospital
  • SUZUKI YOSHIYUKI
    Department of Radiation Oncology, Gunma University Graduate School of Medicine
  • SAKURAI HIDEYUKI
    Proton Medical Research Center and Department of Radiation Oncology, University of Tsukuba
  • NAKANO TAKASHI
    Department of Radiation Oncology, Gunma University Graduate School of Medicine

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Other Title
  • 温熱放射線療法が著効した多形性脂肪肉腫の1例

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Abstract

Pleomorphic liposarcoma (PL) is a rare subtype of liposarcoma that carries a poor prognosis because of the high incidence of local recurrence and metastasis. Here we report the case of a 69-year-old man with bulky re-recurrent PL that showed a remarkable response to hyperthermoradiotherapy.<br> The patient was diagnosed with PL in his right thigh and was treated with total tumorectomy and radiotherapy (50 Gy in 2-Gy fractions in 5 weeks). However, the tumor recurred 9 months after treatment, necessitating a second surgery. A year after the second resection, the tumor recurred again and the patient received hyperthermia (5 sessions in 5 weeks). However, the tumor continued to grow. Subsequently, we decided to administer hyperthermoradiotherapy (a total radiotherapy dose of 40 Gy in 2-Gy fractions and 4 hyperthermia sessions in 4 weeks). After hyperthermoradiotherapy, the tumor shrunk remarkably and did not regrow for 2 years until death. This case report indicates that hyperthermoradiotherapy may be a useful treatment option for patients with recurrent PL.

Journal

  • Thermal Medicine

    Thermal Medicine 29 (3), 63-67, 2013

    Japanese Society for Thermal Medicine

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