Orally administered L-tyrosine, but not D-tyrosine, shortly enters into several regions of the mouse brain

DOI
  • Takagi S.
    Laboratory of Regulation in Metabolism and Behavior, Faculty of Agriculture, Kyushu University
  • Ikeda H.
    Laboratory of Regulation in Metabolism and Behavior, Faculty of Agriculture, Kyushu University
  • Kawase T.
    Laboratory of Regulation in Metabolism and Behavior, Faculty of Agriculture, Kyushu University
  • Nagasawa M.
    Laboratory of Regulation in Metabolism and Behavior, Faculty of Agriculture, Kyushu University
  • Chowdhury V. S.
    Department of Biology, Faculty of Arts and Science, Kyushu University
  • Yasuo S.
    Laboratory of Regulation in Metabolism and Behavior, Faculty of Agriculture, Kyushu University
  • Furuse M.
    Laboratory of Regulation in Metabolism and Behavior, Faculty of Agriculture, Kyushu University

Bibliographic Information

Other Title
  • 経口投与したL-チロシンはD-チロシンとは異なり脳部位に速やかに移行する

Description

Although it was reported that a long term supplementation of dietary L-tyrosine, an amino acid that is a precursor of catecholamine, alleviated the chronic stress induced behaviors, limited information is available on the comparison between the effects of L- and D-tyrosine during acute stress. In the present study, the short term effects of oral administration of L- and D-tyrosine on behavioral alterations induced by acute stress were investigated along with the analysis of these two forms of amino acid concentrations in the mouse brain. Locomotor activity in the open field was not altered by either L- or D-tyrosine. Plasma L-tyrosine concentration was greatly but D-tyrosine was moderately increased after 35 min of the treatment. Interestingly, D-tyrosine concentrations were 1.8-2.5 folds higher compared with L-tryrosine in the several brain sites, namely prefrontal cortex, hippocampus, striatum, thalamus, hypothalamus, brain stem and cerebellum of control mice. In all the brain sites determined, L-tyrosine treatment increased the concentrations of L-tyrosine, but D-tyrosine treatment did not increase D-tyrosine levels. In conclusion, our results suggest that orally administered L- and D-tyrosine did not modify locomotor activity, but transportation of tyrosine into brain may be different between L- and D-tyrosine in mice.

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Details 詳細情報について

  • CRID
    1390001205289367424
  • NII Article ID
    130004951830
  • DOI
    10.11266/jpan.16.67
  • ISSN
    21857601
    13443763
  • Text Lang
    ja
  • Article Type
    journal article
  • Data Source
    • JaLC
    • CiNii Articles
    • KAKEN
  • Abstract License Flag
    Disallowed

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