Identification of Single Nucleotide Polymorphisms in Mouse <i>Tryptophan 2,3-dioxygenase</i> Gene

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  • Kanai Masaaki
    Center for Advanced Research and Education, Asahikawa Medical University Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine
  • Yukari Tomisaki
    Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine
  • Tamura Ai
    Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine
  • Nakamura Toshikazu
    Kringle Pharma Joint Research Division for Regenerative Drug Discovery, Center for Advanced Science and Innovation, Osaka University
  • Funakoshi Hiroshi
    Center for Advanced Research and Education, Asahikawa Medical University Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine

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Other Title
  • 行動パターンの異なるマウス系統間における <i>Tryptophan 2,3-dioxygenase</i> 遺伝子の一塩基多型の同定
  • 行動パターンの異なるマウス系統間におけるTryptophan 2,3-dioxygenase遺伝子の一塩基多型の同定
  • コウドウ パターン ノ コトナル マウス ケイトウ カン ニ オケル Tryptophan 2,3-dioxygenase イデンシ ノ ヒトシオキ タケイ ノ ドウテイ

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Abstract

Mental disorders, such as depression and abnormal behaviors, are increasingly important social and medical issues in 21st century. Nutrients, including tryptophan (Trp) and its metabolites, are thought to be important for healthy mental development. Tryptophan 2,3-dioxygenase (TDO) is one first and rate-limiting enzyme for Trp metabolic pathway, and plays an important role in physiological regulation of systemic Trp metabolism, brain serotonin synthesis, and mood. Here, we analyzed single nucleotide polymorphisms (SNPs) in mouse tdo gene between C57BL/6J mice and BALB/c mice, which exhibits different phenotypes with behavioral analyses. Three SNPs in mouse tdo gene were identified between each strain, and one of three, G87T SNPs, was missense mutation, V18L, in the highly conserved in various species. However, since the expression levels of hepatic TDO protein and TDO enzyme activity were not different between each strain, this mutation might little effect on physiological TDO function in the liver. Further analyses of the association genetic and functional TDO modification with individual character in selective bleeding and mental disorders will be need in companion animal.

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