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- Ichihashi Masamitsu
- Anti-Aging Medical Research Center and Glycation Stress Research Center, Graduate School of Life and Medical Sciences, Doshisha University
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- Yagi Masayuki
- Anti-Aging Medical Research Center and Glycation Stress Research Center, Graduate School of Life and Medical Sciences, Doshisha University
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- Nomoto Keitaro
- Anti-Aging Medical Research Center and Glycation Stress Research Center, Graduate School of Life and Medical Sciences, Doshisha University
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- Yonei Yoshikazu
- Anti-Aging Medical Research Center and Glycation Stress Research Center, Graduate School of Life and Medical Sciences, Doshisha University
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説明
This article reviews glycation stress as a factor linked to age-related diseases and functional and structural alterations of the skin. Photo-aging and glycation stress are major causes of skin deterioration. Glycation occurs when a reducing sugar, such as glucose or fructose, combines with a protein in a non-enzymatic reaction forming a glycated protein. Further reactions form advanced glycation end products (AGEs), which may accumulate in tissue. AGEs may also bind to a receptor for AGEs (RAGE), thus inducing inflammatory changes in skin and other tissues. The concept of glycation stress includes cellular and tissue responses to reducing sugars and aldehydes, not just to the production of AGEs.Glycation stress may be induced and affected by many factors, including exposure to ultraviolet light, which drastically intensifies AGE accumulation. AGEs modify skin collagen by reducing skin elasticity, and one result is wrinkle formation. AGEs accumulated in skin may be detected using auto-fluorescence (AF); our data from 136 healthy Japanese females shows the AF level is correlated with age.Glycation stress, and subsequently skin aging, may be reduced by managing levels of blood glucose, low-density lipoprotein cholesterol, and triglyceride through an appropriate diet, lifestyle, and intake of anti-glycation materials such as AGE generation inhibitors, AGE decomposers, and AGE receptor antagonists. Study of glycation stress may help identify new anti-aging treatments.
収録刊行物
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- ANTI‐AGING MEDICINE
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ANTI‐AGING MEDICINE 8 (3), 23-29, 2011
一般社団法人 日本抗加齢医学会
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詳細情報 詳細情報について
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- CRID
- 1390001205293711232
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- NII論文ID
- 130000968338
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- ISSN
- 18822762
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
- OpenAIRE
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