Evaluation of Hepatitis B Vaccination in Nursing School Students

DOI Web Site 9 References
  • AONO Junko
    Department of Nursing, Yokkaichi Nursing and Medical Care University
  • YOTSUYANAGI Hiroshi
    Department of Infectious Diseases, Internal Medicine, University of Tokyo Hospital
  • MORIYA Kyoji
    Department of Infectious Control and Prevention, Internal Medicine, University of Tokyo Hospital
  • KOIKE Kazuhiko
    Department of Gastroenterology, Internal Medicine, University of Tokyo Hospital

Bibliographic Information

Other Title
  • 看護学生に対するB型肝炎ワクチン接種の評価
  • カンゴ ガクセイ ニ タイスル Bガタ カンエン ワクチン セッシュ ノ ヒョウカ

Search this article

Abstract

  Three hundred and fifteen nursing school students (279 women and 36 men, mean age 18.1±0.6) who entered the school between 2007 and 2009, inclusive, were inoculated with hepatitis B (HB) vaccine, and the immunogenicity of the HB vaccine was evaluated. Seroconversion to anti–HB surface (HBs) antigen by the primary series of vaccinations performed during the first academic year was seen in 97.8% of women and 97.2% of men in April of the second academic year. An additional single dose or full three-dose series induced seroconversion in 100% of both female and male non-responders to the primary series. Among the students who responded to the primary vaccination, 3.9%(5/129) became seronegative (anti–HBs titer, <10 mIU/mL) during the first year, and 10.1%(13/129) during the two years after seroconversion by the primary series of vaccinations. Among those with secondary vaccine failure, booster inoculation induced prompt response, indicating that booster inoculation may not be necessary in the following academic years until graduation. Meanwhile, one student who showed a high level of anti–HBs antibody titers after completion of the primary series of vaccination, transiently became anti–HBs antigen positive, suggesting that vaccination may not prevent HBV infection completely.<br>

Journal

References(9)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top