Impact of Alcohol-Based Hand Antiseptics, Effective against Non-Envelope Viruses, on Hand Skin

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  • ノンエンベロープウイルスに対する効果が改善されたアルコール手指消毒剤の手肌への影響
  • ノンエンベロープウイルス ニ タイスル コウカ ガ カイゼン サレタ アルコール テサシ ショウドクザイ ノ シュハダ エ ノ エイキョウ

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  In recent years, alcohol-based hand antiseptics with improved effectiveness against non-envelope viruses, which are difficult to eliminate, have been introduced into many health care settings. However, only a few studies on the efficacy have been reported. Therefore, we investigated effect of the continuous use of hand antiseptics on hand skin. Forty nurses were divided into two groups, one group used an alcohol-based hand antiseptic with acid pH adjusted with phosphoric acid (Phosphoric acid alcohol, P–AL) and the other used conventional neutral solution for one month during the cold season when skin irritation tends to occur. Transepidermal water loss (TEWL), keratinocyte moisture content, skin pH, keratinocyte exfoliation and run length ratio (RLR) were measured as objective indicators and skin condition was evaluated before and after the study. A questionnaire survey regarding to the hand skin condition was conducted as a subjective indicator. Objective evaluation showed significant improvement in keratinocyte moisture content after the study with the use of P–AL. However, the other objective and subjective indicators found no significant difference between the solutions and no sign of skin irritation. This study demonstrates that the use of P–AL does not harm the hand skin of health care workers even in the cold season when skin irritation tends to occur, and suggests the possibility of continuous use of P–AL for general infection control and prevention against non-envelope viruses.<br>

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