Occurrence of Adverse Effects Related to Vaccination against the 2009 H1N1 Influenza Virus in Healthcare Workers

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  • OKAZAKI Chie
    Department of Pharmacy, Juntendo University Nerima Hospital
  • HORI Satoshi
    Department of Infection Control Science Juntendo University, Graduate School of Medicine
  • MORIMOTO Keiko
    Department of Pharmacy, Juntendo University Nerima Hospital
  • SIMOJIMA Kazuyo
    Department of Pharmacy, Juntendo University Nerima Hospital
  • SASE Kazuhiro
    Department of Clinical Pharmacology, Juntendo University Medical School

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  • 医療従事者における新型インフルエンザワクチン接種後の副反応発生状況
  • イリョウ ジュウジシャ ニ オケル シンガタ インフルエンザワクチン セッシュ ゴ ノ フクハンノウ ハッセイ ジョウキョウ

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Abstract

  The adverse effects of the 2009 H1N1 influenza vaccines against a novel swine-influenza A (H1N1) virus were evaluated in our hospital using a questionnaire on the occurrence of any adverse effects related to the vaccination. Amongst 568 healthcare personnel receiving the vaccine, a total of 415 (73.1%) consisting of 147 men and 268 women agreed to participate and completed the questionnaire. Adverse effects were reported by a total of 71 (17.1%) persons, 15 (10.2%) men and 56 (20.9%) women. The most common effects were swelling and induration at the vaccination site which occurred in 38 (9.2%) recipients, followed by malaise in 26 (6.3%), and cold-like symptoms in 15 (3.6%). No serious adverse effect (>grade 3) was reported. Only two (0.5%) recipients visited a physician after receiving the vaccine, and no causal relationship between their symptoms and the vaccine was observed. This result indicates that the vaccine against the nobel swine-influenza A (H1N1) was as safe as the other seasonal vaccines approved previously. Since the number of recipients was small and most of the recipients were healthcare providers, a larger study on safety amongst children and adults other than healthcare workers is required.<br>

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