胃癌術後免疫療法施行時におけるSu-PS皮膚反応の有用性について

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  • THE USEFULNESS OF THE Su-PS SKIN REACTION TEST FOR GASTRIC CANCER PATIENTS TREATED WITH IMMUNOTHERAPY

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The possibility of using the Su-PS skin reaction as a specific parameter of the therapeutic effect of OK-432 was studied histologically and clinically, and the following results were obtained:<br>1) Infiltration of T cells, macrophages, etc., centering on helper/inducer T cells, was present at the site of the Su-PS skin reaction, showing approximately the same tissue reaction as that at the site of intracutaneous administration of OK-432.<br>2) Changes in the Su-PS skin reaction provided a parameter for evaluating the therapeutic effect of OK-432 and the prognosis of gastric cancer.<br>3) The prognosis of gastric cancer was favorable when the Su-PS skin reaction was increased by more than 10 mm after surgery.<br>4) For evaluation of the prognosis of gastric cancer, it is important to compare the Su-PS skin reaction 6 months and 12 months after surgery with that before surgery.<br>These results indicate that the Su-PS skin reaction provides a parameter which specifically reflects the therapeutic effect of OK-432, and accordingly it provides an index which can be used for evaluation of the prognosis of gastric cancer during administration of OK432.

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