書誌事項
- タイトル別名
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- Small-Molecule Microarrays as Tools for Facilitating Chemical Genomics: Recent Advances
- ケミカルゲノミクス ケンキュウヨウ ツール ト シテ ノ テイブンシ ユウキ カゴウブツ ノ マイクロアレイカ ギジュツ
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説明
The identification of small molecule ligands for cellular proteins of biologically importance has not only provided new insights in biology, but has also provided organic chemists with the opportunity to create new synthetic molecules which efficiently regulate specific protein-protein interactions and biological processes. Small-molecule microarrays are recently developed as platforms to screen such small molecule ligands for proteins of interest. The small-molecule microarray technology is highly dependent on chemistry to immobilize small molecules on a variety of solid surfaces, and synthetic organic chemistry will continue to play a significant role in this field. This review covers the recent advances in the field with particular emphasis on the immobilization chemistry, as well as technical advances in the platform optimization and the successful applications of this platform.
収録刊行物
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- 有機合成化学協会誌
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有機合成化学協会誌 64 (6), 639-650, 2006
公益社団法人 有機合成化学協会
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詳細情報 詳細情報について
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- CRID
- 1390001205311058560
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- NII論文ID
- 10019174253
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- NII書誌ID
- AN0024521X
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- COI
- 1:CAS:528:DC%2BD28XlvV2jt7s%3D
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- ISSN
- 18836526
- 00379980
- http://id.crossref.org/issn/00379980
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- NDL書誌ID
- 7988558
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可