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- 高橋 孝志
- 東京工業大学大学院理工学研究科
書誌事項
- タイトル別名
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- Efficient Syntheses of Natural Products and Their Analogues Using Laboratory Automation Technology
- ゴウセイ コウガクテキ シンギジュツ オ リヨウ シタ テンネンブツ オヨビ ソノ ユウドウタイ ノ コウリツテキ ゴウセイ
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A plenty of human efforts is necessary to perform simply repeating processes such as preparations of synthetic intermediates and building blocks, optimizations of reaction conditions and couplings of building blocks in syntheses of natural products and their analogue libraries. These efforts can be reduced by using an automated synthesis apparatus. It is expected that laboratory automation can realize highly efficient, reproducible and safe synthesis of organic compounds. We report here the application of single reactor automated synthesizers to supply of a synthetic key intermediate of taxol and to preparation of monosaccharide building blocks toward combinatorial oligosaccharide library synthesis. In addition, we also applied multi reactor automated synthesizers to optimization of a primary amide N-glycosylation and to one-pot parallel syntheses of phytoalexin elicitor active oligosaccharides library and LewisX/dimeric LewisX library.
収録刊行物
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- 有機合成化学協会誌
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有機合成化学協会誌 69 (4), 379-392, 2011
公益社団法人 有機合成化学協会
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詳細情報 詳細情報について
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- CRID
- 1390001205312223872
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- NII論文ID
- 10028125455
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- NII書誌ID
- AN0024521X
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- COI
- 1:CAS:528:DC%2BC3MXkvFGlsb4%3D
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- ISSN
- 18836526
- 00379980
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- NDL書誌ID
- 11079596
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
- 使用不可