MAC reagents. Three-components Coupling Reaction with One Carbon Homologation
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- Nemoto Hisao
- Faculty of Pharmaceutical Sciences, Tokushima University
Bibliographic Information
- Other Title
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- ＭＡＣ反応剤－簡便な１炭素増炭型３成分連結反応－
- MAC ハンノウザイ カンベン ナ 1 タンソ ゾウタンガタ 3 セイブン レンケツ ハンノウ
- Three-components Coupling Reaction with One Carbon Homologation
- 簡便な1炭素増炭型3成分連結反応
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Abstract
Recent progress of the synthetic study by using Masked Acyl Cyanides (MAC reagents) is described. Various kinds of electrophiles like organohalides, aldehydes, ketons, α, β-unsaturated carbonyl compounds, 1, 3-diene monoxides, allylic carbonates and so on can be transformed to amides or esters with one-carbon homologation. Several syntheses of optically active compounds were demonstrated. Racemization of the α-position of the resulting amides and esters was effectively inhibited by the nature of MAC reagents since the resulting carbonyl group is masked as an oxymalononitrile form during the transformation steps. Highly effective one-portion reaction for the connection of three components (aldehydes or ketones, MAC reagent having silyl group, amines or alcohols) was newly developed. A new short-step preparation of MAC reagents is also introduced.
Journal
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- Journal of Synthetic Organic Chemistry, Japan
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Journal of Synthetic Organic Chemistry, Japan 62 (4), 347-354, 2004
The Society of Synthetic Organic Chemistry, Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390001205312244864
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- NII Article ID
- 10012854934
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- NII Book ID
- AN0024521X
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- COI
- 1:CAS:528:DC%2BD2cXjtFOlur0%3D
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- ISSN
- 18836526
- 00379980
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- NDL BIB ID
- 6918422
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed
