ChemInform Abstract: Recent Advances in the Synthetic Studies of Nine‐Membered Enediyne Antitumor Antibiotics

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  • Sato Itaru
    Department of Chemistry, and Research and Analytical Center for Giant Molecules, Graduate School of Science, Tohoku University
  • Hirama Masahiro
    Department of Chemistry, and Research and Analytical Center for Giant Molecules, Graduate School of Science, Tohoku University

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  • Recent Advances in the Synthetic Studies of Nine-membered Enediyne Antitumor Antibiotics

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The chromophores of the chromoprotein antibiotics C-1027, kedarcidin, and maduropeptin feature a unique nine-membered enediyne structure in the ansa-macrolide ring and show extremely potent cytotoxicity. Their complicated fused ring systems were recently synthesized and the total synthesis of (−)-maduropeptin chromophore was achieved, which thereby led to the revision of its stereochemical structure.

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