冬虫夏草菌類からの新規生物活性物質の探索

DOI Web Site 参考文献52件
  • 伊坂 雅彦
    タイ国立遺伝子工学バイオテクノロジーセンター (BIOTEC)

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タイトル別名
  • Novel Bioactive Compounds from Insect Pathogenic Fungi
  • トウチュウカソウ キンルイ カラノ シンキ セイブツ カッセイ ブッシツ ノ タンサク

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抄録

Several insect pathogenic fungi, including the Chinese medicine Cordyceps sinensis, have been utilized as folk medicines or healthy foods, and some others are important bioinsecticides. However, most of insect pathogenic fungi, naturally rare species, remain chemically unexplored. We have been investigating the secondary metabolites of insect fungi that were collected in Thailand. The studies led to the isolation and structure elucidation of a number of new compounds with diverse chemical structures. In particular, cordyanhydrides and vertihemiptellides possess hitherto unknown skeletons, whereas cordypyridones and hirsutellones exhibit significant antimalarial and antitubercular activities, respectively. These results demonstrate that insect pathogenic fungi are potent sources of novel bioactive compounds.

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