CHEMICAL ACCELERATORS ON THE PACINIAN CORPUSLE

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  • Pacini氏小体とchemical accelerators
  • Pacini シ ショウタイ ト chemical accelerators

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Abstract

There is at present no conclusive evidence for any direct action of chemiacl agents which induce the excitation of Pacinian corpuscle.<BR>So we tried a screening test what drugs did elicite the action potential most remarkablly.<BR>1) Adrenalin, Acetylcholine, Serotonin (5HT) and Bradykinin in concentration as low as from 10-5 to 10-7 elicited many repetitive discharges of Pacinian corpuscle by means of both intra arterial injection and direct injection in the inner bulb.<BR>2) Krebs' solution at 5°C induced numerous firing too.<BR>3) It was concluded that all agents which elicited repetitive discharges had relation to the change of membrane permeability and vessel contraction and dilatation.

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