CELL PROLIFERATION OF EARLY GASTRIC CANCER

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  • SHICHIJO KOJIRO
    1st Department of Internal Medicine, School of Medicine, Gunma University
  • SUTO HIROSHI
    1st Department of Internal Medicine, School of Medicine, Gunma University
  • KOBAYASHI JIRO
    1st Department of Internal Medicine, School of Medicine, Gunma University
  • OOKI ICHIRO
    1st Department of Internal Medicine, School of Medicine, Gunma University
  • TUKADA MINORU
    1st Department of Internal Medicine, School of Medicine, Gunma University
  • SEKIGUCHI TOSHIKAZU
    1st Department of Internal Medicine, School of Medicine, Gunma University
  • HIGUCHI TUGIO
    1st Department of Internal Medicine, School of Medicine, Gunma University

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Other Title
  • 陥凹型早期胃癌の増殖性に関する研究
  • カンオウガタ ソウキ イガン ノ ゾウショクセイ ニ カンスル ケンキュウ

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Abstract

The uptake of thymidine-H3 by human gastric cancer was studied in vitro, and the resulting labeling of cells was used as an indicator of the proliferative capacity of these tumors.<BR>Superficial concaving type (IIc type) and mixed type (IIc + III, III + IIc type) of early gastric cancer from 7 patients, and Borrmann III type of advanced gastric cancer from 2 patients were studied.<BR>Specimens of tumors were obtained either at the time of biopsy or excision. The specimens incubated for 2 hours at 37°C in a medium consisting of 5cc of human whole blood and 25μC of thymidine-H3. After the incubation, autoradiographs were prepared, and labeled tumor cells were counted on the autoradiographs.<BR>All of the early gastric cancer showed a high number of labeled cells, the rate of labeled cells of total counted cells ranged from 13.4% to 27. 2% (average 22. 9%) In advanced gastric cancer, the percentage of in ranged from 10.3% to 23.4%.<BR>The results of this study are suggested that the tumor cell proliferation of the early gastric cancer was as high as that of the advanced cancer.

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