マムシ蛇 (Agkistrodon halys Blomhoffii) 毒の毒性に関する研究

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タイトル別名
  • BIOLOGICAL TOXICITY OF MAMUSHI-SNAKE VENOM (AGKISTRODON HALYS) AND MORPHOLOGICAL CHANGES CAUSED BY THE VENOM
  • マムシ ジャ Agkistrodon halys Blomhoffii ドク ノ ドクセイ ニ カンスル ケンキュウ トクニ セイブツガクテキ ドクセイ ナラビニ ドク ニ ヨル ケイタイガクテキ ヘンカ
  • とくに生物学的毒性ならびに毒による形態学的変化

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In this paper, the biological toxicity of Mamushi- snake venom and morphological changes caused by the venom are described.<BR>1. LD50. of the venom to ddN male mice weighing 17to 20g. are 19-23γ intravenously, 27-31γ intraperitoneally and 97-118γ intramuscularly.<BR>2. Haemorrhagic action is recognized even in 0.08 γ per 0. 1ml. of the venom, Out of four kinds of land-inhabiting snake-Mamushi -snake venom, Habu-snake venom and Sakishi mahabusnake venom-Mamushi snake venom has the strongest haemorrhagic activity.<BR>3. The haemorrhagic and myolytic action are influenced by pH.<BR>4. The haemorrhagic and lethal activity are inactivated by heating at 70°C for 5 minutes or at 100°C for 1 minute.<BR>5. In mice, and guinea pigs, morphological changes caused by Mamushi-snake venom are as follow.<BR>in mice, inoculated with the venom intravenously, intraperitoneally or intramuscularly, haemorrhagic lesions in the injected portion and degenerative and necrotic lesions in the parenchymal organs are common findings.<BR>In guinea pigs, inoculated intramuscularly, morphological changes are haemorrhage and coagulations-necrosis at the inoculated portion, and degenerative and necrotic lesions in the parenchymal organs. Further, adrenal glands, liver, thymus, lymphnodes and spleen present reactive changes probably due to stressor.<BR>As above montioned, Mamushi snake venom has lethal, haemorrhagic and myonecrotic action. Furthermore it is morphologically considered to have action as stressor.

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