CELLULAR ANTIBODY IN MONONUCLEAR PHAGOCYTES

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  • KURASHIGE SATONORI
    Department of Microbiology, School of Medicine, Gunma University
  • KIMURA YUICHI
    Department of Microbiology, School of Medicine, Gunma University
  • KATO EISUKE
    Department of Microbiology, School of Medicine, Gunma University
  • SAGAWA TAKEZO
    Department of Microbiology, School of Medicine, Gunma University

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Other Title
  • 大単核喰細胞の細胞抗体
  • ダイタンカクク サイボウ ノ サイボウ コウタイ

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Abstract

Mononuclear phagocytes derived from liver, subcutaneous tissue and peritoneal cavity of mouse hyperimmunized with live vaccine of Salmomella enteritidis inhibited intracellular multiplication of the same organisms and resisted to cell degeneration, while mononuclear phagocytes of mouse immunized with killed vaccine or normal mouse did not. Such a resistance of phagocytes was refered to as cellular immunity. Employing immune transfer and immune adherence, cellular antibody was detectable in mononuclear phagocytes of mice hyperimmunized with live vaccine of S. enteritidis. This cellular antibody was specifically reactive against live vaccine and was not absorbed with killed one.<BR>It was discussed in this paper on the origin of the cellular antibody and on antibody producing cell series.

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