アミノ酸混合飼料投与で脂肪肝を発生させたラットに及ぼす20%カゼイン飼料の影響

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タイトル別名
  • Effects of Casein Diet on the Rats Producing a Fatty Liver by Feeding the Diets Consisting of Various Amino Acid Mixtures at Low Levels
  • アミノサン コンゴウ シリョウ トウヨ デ シボウカン オ ハッセイサセタ ラ

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The rats in which an extensive fat accumulation had occurred by feeding the diets consisting of the wheat-, rice and miyazaki-pattern amino acid mixture at low levels were further given 20% casein diet for 4 weeks. The recovery from the fatty liver in these rats was investigated through the determinations of serum triacylglycerol and liver lipids.<BR>The body weight gain of all the experimental rats markedly increased during recovery period as compared with those during the low amino acid diets feeding period. In recovery process, however, there was no difference in the feed efficiency (body weight gain/food intake) among all the experimental groups. The contents of serum triacylglycerol of the experimental rats increased by feeding 20% casein diet and recovered nearly to the normal level. For the hepatic triacylglycerol, all the experimental groups showed intensive decreases compared with those in the rats on the low amino acid diets, and in the miyazaki-pattern diet group, contents of all the hepatic lipid components were less than those of two other experimental groups. The conjugated lipids of the rice-pattern diet group had a tendency to be higher than the wheat-pattern diet group. The amounts of vacuoles in the liver cells of the histological sections decreased and the histochemical findings of hepatic parenchymal cells recovered to the normal. Whereas a few hepatic cell containing Sudan III-positive granules was still found. However fibrosis was not observed. It was indicated from above results that feeding of the casein diet (20% level) to the rats in which an extensive fat accumulation had resulted from the low amino acid diets would be effective for the recovery from a fatty liver.

収録刊行物

  • 栄養と食糧

    栄養と食糧 31 (6), 587-595, 1978

    公益社団法人 日本栄養・食糧学会

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