高コレステロール食投与ラットにおける大動脈内膜の電子顕微鏡的研究

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書誌事項

タイトル別名
  • Electron Microscopic Observations on the Aortic Tunica Intima in Rats Fed High-Cholesterol Diet
  • コウ コレステロールショク トウヨ ラット ニ オケル ダイドウミャク ナイマ

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説明

Effect of the diet containing high-cholestrol and high-fat was studied on aortic tunica intima in rats. The purpose of this study was to investigate diet-induced ultrastructral change of the aorta in the experimental animals by scanning and transmission electron microscopy. Male Wistar-strain rats weighing about 120g were kept for 5 months on a semi purified diet containing 5% cholesterol and 40% non-salted butter as experimental animals (cholesterol-fed rats). The other rats fed commertial laboratory ration served as control.<BR>The results were as follows:<BR>1) By scanning electron microscopic observations, the most conspicuous ultrastructural findings in the cholesterol-fed rats were a formation of many wrinkles on the endothelial surface and change of endothelial form. In addition, numerous leukocytes and a certain number of platelets attached to the endothelial surface.<BR>2) By transmission electron microscopic observations, it was found that fat-containing cells (so-celled foam cell) or immature type of the foam cell at subendothelium of the intima in cholesterol-fed rats.<BR>These morphologic change suggest that diet-induced hypercholesterolemia might be a factor of endothelial injury which would serve as possible initiating events in atherosclerosis.

収録刊行物

  • 栄養と食糧

    栄養と食糧 35 (4), 265-274, 1982

    公益社団法人 日本栄養・食糧学会

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