ラットにおける遅延型アレルギー反応成立に対する栄養条件

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書誌事項

タイトル別名
  • Effect of Nutritional State on Induction of Delayed Cutaneous Hypersensitivity
  • ラット ニ オケル チエンガタ アレルギー ハンノウ セイリツ ニ タイスル

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抄録

In previous report, we demonstrated that PPD skin reaction in rats were converted negative by malnutrition. As the delayed cutaneous-hypersensitivity response is considered to be composed of “sensitization” stage with antigen and “recognition” stage of the test antigen, we analysed the effect of malnutrition on the PPD skin reactivity in “sensitization” and “recognition” stage.<BR>The rats were divided into 8 groups. Four groups were fed 0.5% protein diet (malnourished group) and the left were fed 18% protein diet (control group) for 8 weeks respectively. After that, diet transferred 0.5% protein groups to 18% protein diet and 18% protein groups to 0.5% protein diet.<BR>All the rats were “sensitized” with heat killed tubercle bacilli before diet transfer and PPD was injected after diet transfer at various nutritional stages. Skin reactions were read 24 hours after PPD injection and this stage is considered as “recognition” of the antigen.<BR>All the rats sensitized with tubercle bacilli in malnourished state showed positive PPD reaction when the nutritional state of the rats recovered at the recognition stage after diet transfer. However sixty percent of the rats in the group of not enough recovered nutritionally showed negative, suggesting that the recognition stage are affected by nutritional state. From these results, it is most probable that recognition stage is affected by malnutrition and the sensitization was not affected.

収録刊行物

  • 栄養と食糧

    栄養と食糧 32 (2), 99-104, 1979

    公益社団法人 日本栄養・食糧学会

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