たん白質栄養および群居飼育がラットの成長と寿命におよぼす影響

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タイトル別名
  • Effect of Protein Nutrition and Group Housing on Growth and Longevity in Rats
  • タンパクシツ エイヨウ オヨビ グンキョ シイク ガ ラット ノ セイチョウ

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抄録

Three series of experiments were performed to investigate the effects of the level (10%, 18%, 27% and 36% casein) of protein intake and group housing on growth and longevity of rats. Experiment I, Effect of the level of protein intake on growth and longevity; Experiment II, Effect of group housing on growth and longevity; and Experiment III, Effect of the level of protein intake on the activities of some hepatic enzymes.<BR>The following results were obtained.<BR>(1) In the early growth stage, 27% casein group showed the highest growth rate, followed by 36%, 18% and 10% groups in this order. But the differences due to various diets practically diminished after 20 weeks of age.<BR>(2) Higher protein efficiency ratio was found in males than that in females.<BR>(3) When longevity of rats was evaluated, animals fed higher protein diets (18%, 27% and 36% casein) survived longer than those fed a low protein diet (10% casein). But the maximal longevity was essentially the same in all the groups. Group housing exerted no effect on longevity.<BR>(4) Observations of macroscopic pathological lesions at death revealed that most of the animals had lesions in the lung. The incidence of mammary tumor and hypophysial abnormalities appeared to be greater in the groups fed higher (27% and 36%) casein diets.<BR>(5) Female rats, fed a 10% casein diet, under dense (6 animals per cage) population consumed less food and showed less growth than the corresponding animals individually housed. Animals, fed a 27% casein diet, under dense population developed mammary tumor earlier than the corresponding isolated animals.<BR>(6) With aging, the level of serum gamma globulin rose and the A/G ratio was decreased concomitantly.<BR>(7) Within the first couple of weeks after birth, serum alkaline phosphatase appears to originate from organs other than small intestine. With aging, the activity of the enzyme gradually decreases and changes to small-intestinal origin.<BR>(8) Catalase, ATPase and alkaline phosphatase activities in the liver were found to be unchanged with respect to age, sex or the level of protein intake of the animals. Hepatic histidase activity in female rats, however, showed progressively smaller inducibility by a high protein diet with aging. These results do not support M.H. Ross's contention that one can predict life expectancy of rats by simply assaying these several hepatic enzymes.

収録刊行物

  • 栄養と食糧

    栄養と食糧 32 (2), 123-134, 1979

    公益社団法人 日本栄養・食糧学会

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