The Diurnal Rhythms of Intestinal Digestive Enzymes in Diabetic Rats

DOI Web Site
  • SASAKI Mitsuyoshi
    Department of Nutrition, School of Health Sciences, Faculty of Medicine, University of Tokyo
  • YAMADA Kazuhiko
    Department of Nutrition, School of Health Sciences, Faculty of Medicine, University of Tokyo
  • GODA Toshinao
    Department of Nutrition, School of Health Sciences, Faculty of Medicine, University of Tokyo
  • MORIUCHI Sachiko
    Department of Nutrition, School of Health Sciences, Faculty of Medicine, University of Tokyo
  • HOSOYA Norimasa
    Department of Nutrition, School of Health Sciences, Faculty of Medicine, University of Tokyo

Bibliographic Information

Other Title
  • 実験的糖尿病白ネズミにおける膜消化酵素の日内変動
  • ジッケンテキ トウニョウビョウ ハク ネズミ ニ オケル マク ショウカ コウ

Search this article

Description

The diurnal rhythms of intestinal digestive enzymes were observed in streptozotocin-induced diabetic rats. Rats were raised under artificial light (light; 9: 00-21: 00, dark; 21: 00-9: 00) and fed during the dark. Water was given ad libitum.<BR>Diabetic rats showed high concentration of blood glucose and urinary glucose. The body weight gain of diabetic rats was less than that of normal rats. However, the wet weight of intestinal mucosa in diabetic rats was significantly increased as compared with normal rats, especially in the dark.<BR>A typical diurnal rhythm of sucrase activity, specific and total activity, which is low in the light and high in the dark, was observed in normal rats. On the other hand, in diabetic rats, the specific activity of sucrase increased in the light, and was similar or decreased in the dark compared with normal rat, especially in duodenum and jejunum. Therefore, the diurnal variation of specific activity of sucrase was smaller in diabetic rats than in normal rats. However, a typical diurnal rhythm was shown in total activity. Isomaltase activity showed similar pattern as sucrase activity.<BR>Alkaline phosphatase activity showed a diurnal rhythm in normal and diabetic rats.

Journal

  • Eiyo To Shokuryo

    Eiyo To Shokuryo 33 (3), 185-189, 1980

    JAPAN SOCIETY OF NUTRITION AND FOOD SCIENCE

Details 詳細情報について

Report a problem

Back to top