ラットの脳内トリプトファンとセロトニン代謝に及ぼす飼料の影響

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書誌事項

タイトル別名
  • Effect of Diet on Metabolism of Brain Tryptophan and Serotonin in Rats
  • ラット ノ ノウナイ トリプトファン ト セロトニン タイシャ ニ オヨボス

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説明

Influence on brain serotonin (5-HT) as a parameter of brain function was investigated when rats were given diets contained amino acid mixture.<BR>The results obtained were as follows:<BR>(1) In the rats fed the diet without competing amino acids, serum total and free tryptophan (Try), brain 5-HT were elevated.<BR>(2) In the rats fed the diet containing half amount of competing amino acids, plasma total and free Try did not change, but free valine, leucine, isoleucine, phenylalanine, and tyrosine levels in plasma decreased, whereas brain Try and 5-HT increased.<BR>(3) In the rats fed the diet added 0.5% Try, total and free Try in plasma, brain Try and 5-HT increased and the competing amino acids except phenylalanine did not change.<BR>(4) In the rats fed 30% fat diet, plasma free Try increased but plasma total Try, competing amino acids except phenylalanine, and brain Try and 5-HT did not changed.<BR>The multiplecorrelation coefficients between brain Try and plasma total Try and plasma total Try with competing amino acids were higher than the correlation coefficients between brain Try and plasma free Try.<BR>This result suggests that brain Try and 5-HT turnover were influenced by plasma total Try and competing amino acids but not by plasma free Try.<BR>It's presumed that difference of amino acid composition in food influences quickly and complicatedly on brain 5-HT concentration, and that effects of diets on usual brain function are important.

収録刊行物

  • 栄養と食糧

    栄養と食糧 33 (2), 67-73, 1980

    公益社団法人 日本栄養・食糧学会

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