放射線増感剤Misonidazoleの中枢神経毒性に関する実験的研究

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書誌事項

タイトル別名
  • EXPERIMENTAL STUDY ON CENTRAL NERVOUS TOXICITY OF 'MISONIDAZOLE' A HYPDXIC CELL RADIOSENSITIZER
  • ホウシャセン ゾウカンザイ Misonidazole ノ チュウスウ シンケイ
公開日
1981
DOI
  • 10.2974/kmj1951.31.437
公開者
北関東医学会

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説明

Misonidazole', a radiosensitizer for hypoxic cells is expected to be applied to the treatment of malignant tumors, but its side effect becomes a subject of study, because its effective dose is close to its lethal dose. The auther performed experiments with mice on the central nervous toxicity, which is the most lethal of the side effects of Misonidazole, with the following results ;<BR>1. The abrupt death seen after the administration of a large dose of Misonidazole was attributable to the central nervous toxicity. LD50 for d.d. strain mouse was 1.55 mg per body weight g.<BR>2. The used mice always developed convulsion before death. But the administration of anticonvulsant failed to free them from death.<BR>3. Autopsy findings were such abnormal ones as the degeneration and exfoliation of nerve cells and diapedetic focus. After sacrifice, however, no findings indicative of disturbance of central nerve could be detected.<BR>4. Misonidazole, even in a small divided dose, left intracerebral retention, though slightly, indicating that its accumulation in the brain would be increased with increase in the dose.<BR>5. The disturbance of central nerve was not exacerbated by the whole brain irradiation with Misonidazole.

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