EFFECTS OF VARIOUS HORMONES UPON THE EXCRETION OF RADIOACTIVE RUBIDIUM AND ITS DISTRIBUTION IN THE BODY

Rb⁸⁶ Cl was subcutaneously given, in a dose of 1μc/0.1ec, to male mice of dd strain weighing about 20g, and effects of various hormones upon its excretion and distribution in the body were investigated with the following results 1) The administraions of cortisone, hydrocortisone, 9χ-FHC, and Δ′-9α-FHC all showed tendency to accelerate the excretion of Rb⁸⁶. The concentration in various organs tended to be decreased by the administration of 9α-FHC, but showed scarcely any remarkable change after the administration of cortisone, hydrocortisone and Δ′-9α-FHC. 2) The administration of either DOCA or aldosterone produced significant increase in the excretion. As for the concentration in various organs, tendency of decrease was observed in the liver after the administration of DOCA, but no remarkable change in other organs. The administration of aldosterone in 10γ produced tendency of decrease in muscle, and in a dose of 50γ it produced the same in the testis and kidney, but no remarkable change in other organs.<BR>3) The administration of either adrenaline or nor-adrenaline exerted inhibitory effect on the excretion. The administration of adrenaline produced tendency of decrease in the liver, no remarkable change in the testis and blood, and tendency of increase in other organs. The administration of nor-adrenaline produced no remarkable change in the liver and muscle, and tendency of increase in other organs. 4) The administration of thyroxine tended to accelerate the excretion, and to decrease the concentration in the organ. 5) The administration of insulin tended to accelerate the excretion, but produced no remarkable change in the distribution in organs. 6) The administration of testosterone propionate tended to increase the excretion and to decrease the concentration in organs. After the administration of estradiol benzoate, the excretion was rather inhibited, and concentrations in various organs all tended to increase. 7) As for the effect of hormones of the anterior lobe of the hypophysis, GH tended to inhibit, and TSH and ACTH to accelerate the excretion. None produced any remarkable change in the concentration in the organ. 8) The administration of vasopressin produced no remarkable change in the excretion and the concentration in the organ.