甲状腺クリーゼの臨床的観察

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書誌事項

タイトル別名
  • CLINICAL OBSERVATIONS ON THYROID CRISIS
  • コウジョウセン クリーゼ ノ リンショウテキ カンサツ トクニ ケッチュウ コ
  • CHANGES IN BLOOD THYROID HORMONE LEVELS
  • 特に血中甲状腺ホルモンの変動について

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説明

Thyroid crisis is an exaggerated or decompensated stage of thyrotoxicosis. Although the clinical features and precipitating causes are well known, the pathogenesis of thyroid crisis remains obscure.<BR>Six patients with thyrotoxicosis and typical features of thyroid crisis were studied. The serum levels of protein-bound-iodine (PBI) observed in crisis do not differ significantly from the value observed in 10 patients with uncomplicated thyrotoxicosis. In a case of crisis, both serum thyroxine and triiodothyronine levels were slightly elevated during the crisis compared to the value found before crisis and markedly decreased after an extensive treatment with Lugol's solution, propylthiouracil, propranolol and steroid. The precise contributions of adrenal cortex or medulla on the thyroid crisis have not been determined.<BR>It should be pointed out that serum concentrations of thyroid hormones in crisis are not discernibly different from those in uncomplicated thyrotoxicosis. The pathogenesis of thyroid crisis may be related to the increased susceptibility of peripheral tissues to a given dose of thyroid hormones, including possible increased free hormone concentrations.

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