体外循環, 及び表面冷却低体温時の電解質代謝

DOI Web Site

書誌事項

タイトル別名
  • STUDIES ON ELECTROLYTES METABOLISM IN SERUM AND TISSUES DURING EXTRACOPOREAL CIRCULATION AND SURFACE COOLING
  • タイガイ ジュンカン オヨビ ヒョウメン レイキャク テイ タイオンジ ノ デ
  • 殊に組織内変動に関して

この論文をさがす

抄録

The significance of electrolytes in cardiovascular surgery is well known. Recently it has been shown that changes of electrolytes, especially hypopotassemia, occures during cardiopulmonary bypass and surface cooling.<BR>Most previous studies have pointed out a drop in serum potassium level. It is said that this phenomenon is due to anesthesia, hemodilution, length of perfusion, glycemia, administration of diuretics, digitalis, or urinary loss of potassium.<BR>Clinical studies on surgery for the patients with congenital heart diseases and experimental studies of mongrel dogs was performed. Extracoporeal perfusion was performed with bubble oxygenators. Perfusion was performed at 25% hemodilution using blood and lactate Ringer's solution in clinical and experimental studies. And moderate hypothermia was performed with surface cooling.<BR>1) Results obtained were as follow : <BR>a) Potassium level of R.B.C. changed little. But serum potassium level decreased during perfusion, especially in hypothermic perfusion and surface cooling.<BR>Its level gradually returned to precooling level by warming in experimental surface cooling.<BR>b) Potassium level of striated muscle decreased in the course of perfusion. especially it is remarkable in hypothermic perfusion, and also in experimental surface cooling.<BR>c) Potassium level of heart muscle decreased in the course of perfusion, especially in the case of aortic clamping and artifical ventricular fibrillation, while calcium level increased.<BR>d) Potassium level of striated muscle correlated with that of R.B.C. in clinical studies.<BR>e) Potassium level of the liver increased in hypothermic perfusion and surface cooling.<BR>2) Conclusion : <BR>It has been said that hypopotassemia caused by anesthesia, hemodilution, prolonged perfusion, administration of digitalis or diuretics. and urinary loss of potassium during the perfusion, <BR>But during the perfusion and surface cooling, metabolism of the periperal tissues, such as striated muscle were more disturbed than the principal tissues, such as liver including a lot of intra-cellular organellae.<BR>In spite of decrease of temperature, metabolism of the liver is maintained in relatively high level, and in such condisions serum potassium is transported to the liver.<BR>It is considered that hypothermic state is an important factor contributing to hypopotassemia in the course of perfusion.

収録刊行物

詳細情報 詳細情報について

問題の指摘

ページトップへ