Investigation of the risk factor for foot complications in subjects with diabetic nephropathy

DOI Web Site 12 References
  • Hayashi Akinori
    Endocrinology, Diabetes & Metabolism, Kitasato University School of Medicine
  • Moriya Tatsumi
    Endocrinology, Diabetes & Metabolism, Kitasato University School of Medicine

Bibliographic Information

Other Title
  • 糖尿病性腎症患者における重症足病変発症危険因子の検討
  • トウニョウビョウセイジンショウ カンジャ ニ オケル ジュウショウ ソク ビョウヘン ハッショウ キケン インシ ノ ケントウ

Search this article

Description

Objective: Among diabetic patients, end-stage renal disease, in particular hemodialysis, relates to the occurrence of diabetic foot. We investigated the foot complications among diabetic nephropathies before hemodialysis. Methods: There were 106 patients [80 male, average age 62.0 (33–80) years, diabetic duration 17.7±8.8 years, HbA1c (NGSP) 7.7±1.5%, serum creatine 1.9±0.9 mg/dl, eGFR (estimated glomerular filtration rate) 33.0±14.5 ml/min/1.73m2]. We evaluated the occurrence of the foot complications and analyzed the risk factors by the Cox proportional hazards model. Results: The mean observation period was 32.4±22.2 months, and 10 patients underwent therapy for diabetic foot. By multivariate analysis, smoking, diastolic blood pressure and serum creatinine level were significantly associated with the event of diabetic foot [hazard ratio (HR): 13.0, 95% confidence interval (CI): 1.16–435.8, HR: 1.18, 95% CI: 1.03–1.37, HR: 9.03, 95% CI: 1.05–123.6]. Conclusions: It was suggested for the optimal prevention of diabetic foot complications, a multilateral approach was necessary, especially life-support instruction for smoking cessation and therapeutic intervention for hypertension and renal dysfunction.

Journal

References(12)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top