Role of Mechanical Forces and Its Molecular Mechanisms in Wound Healing

DOI
  • Ogawa Rei
    Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School
  • Huang Chenyu
    Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School
  • Akaishi Satoshi
    Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School
  • Sano Hitomi
    Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School
  • Hyakusoku Hiko
    Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School

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Other Title
  • 創傷治癒における物理的刺激の役割とその分子メカニズム
  • －Mechanobiology and Mechanotherapy－
  • －メカノバイオロジーとメカノセラピー－

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Abstract

The three-dimensional structure of living organisms is influenced by various physical factors, including gravity, atmospheric pressure, and water pressure. Thus, mechanobiology is important in the field of wound surgery. Mechanobiology is an emerging field of science which focuses on the way that physical forces and changes in cell or tissue mechanics contribute to development, physiology, and disease. Cells convert intrinsic and extrinsic mechanical stimuli into electrical signals through mechanoreceptors (mechanosensors) such as mechanosensitive ion channels, cell adhesion molecules, and actin filaments in the cytoskeleton. This signal conversion results in accelerated cell proliferation and matrix maturation during the course of tissue growth. Skin and soft tissues are organs those are always affected by mechanical forces, thus wound surgeons need to know the mechanobilogy and mechanotherpay for surgery, wound healing and tissue repair and regeneration.

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